Search results for "benefits and limitations"

showing 3 items of 3 documents

Il ruolo del white paper sulle offerte al pubblico di cripto-attività alla luce della proposta MiCA

2022

La proposta MiCA, nel regolare il white paper sulle offerte di crypto-assets, sembra tenere in considerazione i benefici e i limiti dei sistemi di voluntary e di mandatory disclosure, non optando integralmente né per il primo, né per il secondo. In quest’ottica, se può condividersi l’approccio regolamentare diretto a graduare, a seconda della tipologia di token offerto, sia il contenuto che l’assoggettamento del documento a mera notifica o ad approvazione ex ante da parte dell’Autorità competente, dubbi sorgono in ordine all’indistinta allocazione dell’onere della prova in capo all’oblato, nei casi di violazione della disciplina del relativo white paper.

The MiCa proposal in the regular white paper on crypto-assets offerings seems to take into account the benefits and limitations of voluntary and mandatory disclosure systems not opting for either the former or the latter in full. On one hand one can agree with the regulatory approach aimed at adapting the content of the white paper to the type of token offered and at making the white paper either subject to mere notification or to the approval by the competent Authority depending on the asset offered. On the other hand doubts arise on the indistinct allocation of the burden of proof to the user in case of infringement of the relevant white paper framework.Settore IUS/04 - Diritto Commerciale
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Stem Cell Therapy

2019

The necessity of improving the health and quality of life of subjects affected by diverse injuries and chronic diseases, has led to develop a new branch of translational medicine, called Regenerative Medicine (RegMed). RegMed has the principal objects of restoring, maintaining or enhancing structures and functions of tissues and organs. In order to achieve these goals, the RegMed researchers have proposed and tested diverse approaches. The Stem Cell Therapy represents the central focus of RegMed, even if its applications may imply the onset of adverse conditions. Here, an overview of this topic will be reported, by pointing advantages and disadvantages.

mesenchymal stem cellsbusiness.industrymedicine.medical_treatmentfibrosisregenerative medicineStem-cell therapybenefits and limitationsstem cell therapyangiogenesistranslational medicinegrowth factors/cytokinesCancer researchSettore MED/05 - Patologia ClinicaMedicinebusinessangiogenesis; benefits and limitations; fibrosis; growth factors/cytokines; mesenchymal stem cells; regenerative medicine; stem cell therapy; translational medicine
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Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascend…

2022

Aorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies, currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult to manage, being insidious and silent pathologies whose diagnosis is based only on imaging data. No diagnostic and prognostic biomarkers or markers of outcome have been known until now. Thus, their identification is imperative. Certainly, a deep understanding of the mechanisms and pathways involved in their pathogenesis might help in such research. Recently, the key role of oxidative stress (OS) on the pathophysiology of aorta disease has emerged. Here, we describe and discuss these aspects by revealing some OS …

potential biomarkersPhysiologyClinical Biochemistryaorta diseasesascending aorta aneurysm (AsAA)Cell Biologybenefits and limitationsreactive oxygen species (ROS)BiochemistrySettore MED/23oxidative stressSettore MED/05 - Patologia Clinicapotential treatmentsMolecular BiologyAntioxidants (Basel, Switzerland)
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